So I went to update all my CS5.5 last night and ended up spending hours trying to get the application manager to actually allow me to update. I kept getting an error saying "You are already running the Adobe Application Manager. Please close all instances of Adobe Application Manager in order to continue with this installation."
Now I had been getting this error for a while, on two (OSX) machines so I decided that enough was enough and needed to get this running. I knew I only had one instance running, I had checked
top multiple times to confirm this. So after much research I figured out that it was simply a permissions problem, so who better to alleviate a permissions problem than my good friend
sudo /Library/Application\ Support/Adobe/OOBE/PDApp/core/Adobe\ Application\ Manager.app/Contents/MacOS/PDApp
And that was it! The Application Manager ran without that annoying message.